Axial Therapeutics™ is a clinical-stage biopharmaceutical company focused on the discovery and development of gut-restricted, small molecule therapeutics for central nervous system (CNS) disorders. The company is leveraging its expertise in the gut-brain axis and its unique drug development platform to advance novel therapies that have the potential to transform the treatment paradigm in neurodegenerative diseases. Axial is advancing a pipeline of small molecule product candidates with lead clinical programs that address underlying pathology and resulting disease symptoms in Autism Spectrum Disorder (ASD) and Parkinson’s Disease (PD), and additional preclinical initiatives in small molecules in other areas of autism and PD, as well as oncology and rare CNS diseases.

To apply, please send your resume and cover letter to careers@axialtx.com.

SCOPE

This is a challenging role for a scientist who is a self-starter with excellent communication skills to set-up and lead our in vivo pharmacology efforts. You will report to the Senior Vice President, Research and Development.

Essential Duties and Responsibilities
  • Lead internal effort for identifying relevant animal models of disease for neurodegenerative and neurodevelopmental disorders; will require significant interaction with Axial scientists, development team, co-founders and Scientific Advisory Board
  • Provide key to therapeutic discovery and development programs by contributing to translational strategy from lab to clinic
  • Depending on level, supervise pharmacology team or potentially all of internal biology team
  • Identify and qualify specialty CRO’s for in vivo pharmacology studies
  • Directly and indirectly manage in vivo studies done at Clinical Research Organizations (CRO’s) and/or collaborators
  • Directly and indirectly design and execution of animal studies
  • Contribute to interpretation of clinical pharmacology data and preparation of final clinical study reports
  • Contribute to the writing of relevant reports that may be included in regulatory fillings
  • Participate in Company planning and strategy
Qualifications
  • PhD or equivalent with 10+ years of relevant biotech or pharma experience, preferably in neurology/neuropharmacology/neurodegeneration/neuroinflammation or related field
  •  Demonstrable experience with drug discovery and neurologic diseases preferred
  • Experience in models and studies involving germ-free animals preferred
  • Ability to manage multiple projects and identify and resolve issues
  • At ease in small biotech organizations, with ability to operate at strategic and detailed levels and the ability to perform under challenge, in fast-moving environments
  • Thrives in matrix management structure that relies on team approach
  • Establishes good relationships and communicates clearly at all levels within the organization, contributes to building a supportive Corporate culture
  • Able to serve as positive mentor for scientists
  • Excellent interpersonal and writing skills
  • Results oriented with excellent decision-making skills

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Scope of Role

In this role the Research Associate will support biology as a member of a highly matrixed drug discovery team and will be responsible for the execution and troubleshooting of various biological assays and experiments.  This pro-active researcher will collaborate with team members, identify opportunities to improve efficiency, share ideas and expertise and contribute to Axial’s creative, dynamic and collaborative culture.

Essential Duties and Responsibilities

  • Provide critical laboratory support while working as part of an energetic, collaborative team
  • Assist with the optimization and validation of cell-based or biochemical assays to support ongoing discovery projects
  • Use cellular or biochemical assays to characterize small molecules and biologics that modulate pathways relevant to pathological processes driving neurological diseases or cancer
  • Analyze and report data to multidisciplinary teams of scientists internally
  • Maintain excellent and detailed records in an electronic notebook
  • Prepare laboratory reagents and order supplies and equipment

 

Qualifications

  • Careful, thoughtful and collegial bench scientist with experience and proficiency with a variety of molecular and cell biology techniques such as cell culture, Westerns or ELISA, PCR, transfections or transformations, and protein purification
  • Strong scientific curiosity, ability to rapidly learn new laboratory and data analysis methods
  • Self-starter with strong problem-solving abilities and resourcefulness, and an outstanding team player with ability to work in groups as well as independently
  • Highly detail-oriented and organized with strong analytical skills
  • Ability to multitask, prioritize, and function in a fast-paced, entrepreneurial environment
  • Bachelor’s degree in biology, biochemistry or a related field preferred, with at least 1-3 years of relevant lab experience
  • Experience supporting drug discovery programs preferred

TO APPLY: Please visit https://axialtx.com/careers/

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Scope of Role

In this role, the Research Associate will apply critical thinking, careful technical execution and aptitude for developing new dosage forms. The individual will develop oral modified release solid dosage forms for different therapeutics. This pro-active researcher will collaborate with fellow team members, ensure the smooth function of the lab, look for opportunities to improve efficiency, and share ideas and expertise. They will contribute to Axial’s creative, dynamic and collaborative culture and advance new therapies targeting the gut-brain axis to help patients with neurological diseases and disorders.

Essential Duties and Responsibilities
  • Utilize formulation equipment, such as fluidized bed coater, tableting machine, etc.
  • Develop and execute design of experiments (DOE) to explore modified release formulations for tablet/capsule/bead dosage forms\
  • Evaluate the effect of formulation and processing factors on the physical and release characteristics from the dosage forms
  • Analyze and report data to multidisciplinary teams
  • Share ideas, creativity and critical thinking across functions, inside and outside the lab, and embrace input from teammates
  • Maintain detailed records in an electronic notebook, promote safety and compliance in a BL2 laboratory environment, and contribute actively to the smooth operation of the lab
Qualifications
  • Prior work experience with tableting, encapsulation and air suspension granulation/coating
  • Self-starter with strong problem-solving abilities, resourcefulness, scientific curiosity and desire to learn
  • Outstanding team player with excellent track record working in groups as well as independently, with outstanding and proactive communication
  • Highly detail-oriented and organized, with strong analytical skills and experience reporting data
  • Ability to multitask, prioritize, and function in a fast-paced, entrepreneurial environment
  • Graduate student or experienced undergraduate student in pharmaceutical sciences or relevant polymer sciences field

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Note to Employment Agencies

Axial Therapeutics™ values our relationships with our Recruitment Partners and will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Axial Therapeutics™ is not responsible for any fees related to resumes that are unsolicited or are received by any employee of Axial Therapeutics™ who is not a member of the Human Resources team.